Epileptogenic Role of Astrocyte Dysfunction
نویسندگان
چکیده
منابع مشابه
The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis
Astrocytes are the most populous glial subtype and are critical for brain function. Despite this, historically there have been few studies into the role that they may have in neurodegenerative diseases, such as Parkinson's disease (PD). Recently, however, several studies have determined that genes known to have a causative role in the development of PD are expressed in astrocytes and have impor...
متن کاملInfluence of Striatal Astrocyte Dysfunction on Locomotor Activity in Dopamine-Depleted Rats
Introduction: Astrocyte dysfunction is the common pathology resulting in failure of astrocyte-neuron interaction in neurological diseases, including Parkinson’s Disease (PD). To date, only few experimental models of selective ablation of astrocytes are known. The aim of present study was to evaluate the effect of striatal injections of selective glial toxin L-aminoadipic acid (L-AA) on the loco...
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The IKK/NF-κB signal transduction and transcription factor system is a central regulator of inflammation, cell survival and differentiation, and is implicated in multiple human pathologies including multiple sclerosis, glioblastoma and neurodegenerative disorders. The IKK/NF-κB system is prominently activated by proinflammatory cytokines and molecules derived from pathogens or damaged cells and...
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ژورنال
عنوان ژورنال: Epilepsy Currents
سال: 2008
ISSN: 1535-7597,1535-7511
DOI: 10.1111/j.1535-7511.2008.00233.x